Lifenol™

Naturally supporting menopausal symptoms and bone health

Disclaimer
This web page is intended to provide business-to-business education and information.Its purpose is not intended to communicate to end consumers. Ingredient information is for educational purposes only; specific ingredients are not intended to prevent, treat, mitigate or cure any disease states.
Disclaimer
This web page is intended to provide business-to-business education and information.Its purpose is not intended to communicate to end consumers. Ingredient information is for educational purposes only; specific ingredients are not intended to prevent, treat, mitigate or cure any disease states.
Disclaimer
This web page is intended to provide business-to-business education and information.Its purpose is not intended to communicate to end consumers. Ingredient information is for educational purposes only; specific ingredients are not intended to prevent, treat, mitigate or cure any disease states.
Disclaimer
This web page is intended to provide business-to-business education and information.Its purpose is not intended to communicate to end consumers. Ingredient information is for educational purposes only; specific ingredients are not intended to prevent, treat, mitigate or cure any disease states.
Disclaimer
This web page is intended to provide business-to-business education and information.Its purpose is not intended to communicate to end consumers. Ingredient information is for educational purposes only; specific ingredients are not intended to prevent, treat, mitigate or cure any disease states.

Improving women’s quality of life with our science-backed hops extract

Powered by a patented hops extract and awarded health claims, Lifenol™ has been proven in gold-standard clinical trials to relieve uncomfortable menopausal symptoms,¹ ² such as hot flashes, while also supporting total bone-mineral density.³ Lifenol™ offers scientifically-substantiated benefits for menopause. It’s the natural way to improve menopausal quality of life.
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Benefits

Menopausal health
Bone health

Women want natural solutions for menopausal symptoms

Each year, millions of women enter menopause –  the permanent cessation of menstruation for at least 12 months. It’s caused by natural changes in hormonal levels with age – most notably, a decline in 17-β-estradiol, the main type of oestrogen in the human body.⁴ Menopausal symptoms can have a significant, negative impact on women’s quality of life. Around 75% of women in the U.S. are affected by hot flashes and night sweats, while 45% suffer from psychogenic symptoms such as disturbed sleep.⁴ Low oestrogen levels are also the primary cause of postmenopausal bone loss, because oestrogen is the main hormonal regulator of bone metabolism. With increasing life expectancy, some women will spend up to 40% of their lives in the post-menopausal stage.⁴ Clinical research shows that Lifenol™, made from hops, addresses women’s menopausal symptoms with a 100% natural solution.² ³

Clinically proven

in three randomised, placebo-controlled trials published in peer-reviewed journals

Supported by authorised health claims

in Canada and South Korea

Efficacy for a range of menopausal symptoms

including hot flashes, sleep disturbances and low bone mass (osteopenia)

Improves menopausal symptoms

in 6 weeks²

100% natural

made from sustainably grown and fully-traceable hops from Germany

Want to know more about OatWell™'s unique characteristics?

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The science behind

Lifenol™

Hops: clinically proven to improve menopausal symptoms

Lifenol™ is a natural, low-dose solution delivering effective phytoestrogen, prenylnaringenin (8-PN). A single 85 mg dose has been clinically shown to alleviate distressing menopausal symptoms such as hot flashes and sleep problems in two separate studies.² ³ It is also clinically demonstrated to support bone health.³

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Lifenol™

responsible sourcing

Sustainable and fully traceable hops

Lifenol™ is sourced from the hops capital of the world – Hallertau in Germany. The hops we use to produce Lifenol™ are grown and harvested sustainably, in accordance with the principles of our Sourcing4Good programme, which promotes responsible practices across our supply chains, while improving both producer livelihoods and the environmental impacts of our products. The hops used in Lifenol™ enjoy full traceability from field to final product. 

Our hops suppliers are committed to our responsible sourcing practices, and we work closely with them to drive tangible actions to protect and promote the environment and the wellbeing of the communities where we source ingredients.

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Lifenol™: Advanced agricultural practises

Traditional medicine backed by modern science

Hops are the female flowers or seed cones of Humulus lupulus, a climbing vine with a long history of use in beer making. In North American traditional medicine, hops were used both to alleviate breast and womb problems, and as a sleep aid. ⁷ In 1953, Koch and Heim discovered that hops had oestrogenic properties, but were unable to identify the active substance.⁸ Nearly 50 years later, in 1999, Milligan et al reported that hops’ estrogenic effect was caused by a unique molecule: 8-prenylnaringenin, known as 8-PN – a naturally occurring plant phytoestrogen. ⁸

Why formulate

with

Lifenol™

?

Lifenol™ has a long history of use in the global dietary supplement market. Because of its small effective dosage, it’s ideal for use in a range of nutraceutical formats, including tablets and capsules.
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FAQs

1. How fast does Lifenol™ work to relieve menopausal symptoms?
2. Is there a menopausal symptom that Lifenol™ best addresses?
3. I’m already taking calcium and vitamin D. Will Lifenol™ provide additional support?

We would love to hear from you!

If you have a specific product in mind or are curious about how we can assist in your innovation journey, please don't hesitate to get in touch
Contact us
References

Lifenol™

The natural adaptogen backed by science

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The science behind Lifenol™

Clinically proven benefits for menopausal symptoms

Lifenol™ is a natural, low-dose solution delivering effective phytoestrogen, prenylnaringenin (8-PN). A single 85 mg dose has been clinically shown to alleviate distressing menopausal symptoms such as hot flashes and sleep problems in two separate studies.² ³ It is also clinically demonstrated to support bone health.³

1%
increase in bone mineral density³
Improves menopausal symptoms in as little as 6 weeks²

Effectively managing menopausal symptoms

Two independent, randomised, double-blind, placebo-controlled trials have demonstrated that Lifenol™ effectively manages menopausal symptoms, including hot flashes and sleep disturbances. 

  • In the first study, after six weeks of taking 85 mg of Lifenol™ daily, postmenopausal women saw their hot flashes reduced from between two and five per day to less than two per day. They also reported a significant reduction in other symptoms, including night sweats and sleep disturbances, compared to placebo.²
  • The second study found that postmenopausal women switching from eight weeks on placebo to eight weeks on 85 mg of Lifenol™ daily experienced a reduction in menopausal discomfort.² On the other hand, those moving from Lifenol™ to placebo reported a slight increase in symptoms.²

Supporting healthy bone density

A 2023 clinical study – another gold-standard, randomised, double-blind, placebo-controlled trial – has shown that Lifenol™ supports bone health in postmenopausal women with osteopenia.³ Supplementation with 85 mg per day for 48 weeks, along with standard-of-care vitamin D3 and calcium daily supplementation, significantly improved total bone mineral density by 1.8% compared to baseline.³

What’s really interesting is that it increased by 1% compared to supplementation with vitamin D3 and calcium alone. The participants taking Lifenol™ also reported a significant improvement in their physical quality of life and functional health (like participating in vigorous physical activity) compared to placebo.

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Approved health claims

Based on the strong scientific evidence, Lifenol™ has been awarded health claims in two countries.  - The South Korean Ministry of Food and Drug Safety has authorised the health claim on Lifenol™ + Soy extract blend: “May help to maintain female health in menopause.” ⁵ - Health Canada has granted LifenolTM a Natural Product Number and the health claim: “May help relieve menopausal discomforts/complaints.” ⁶

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Approved health claims

Based on the strong scientific evidence, Lifenol™ has been awarded health claims in two countries.

The South Korean Ministry of Food and Drug Safety has authorised the health claim on Lifenol™ + Soy extract blend: “May help to maintain female health in menopause.” ⁵

Health Canada has granted Lifenol™ a Natural Product Number and the health claim: “May help relieve menopausal discomforts/complaints.” ⁶

References

Lifenol™ Responsible Sourcing

Cultivating hops the traditional way

Hops thrive in temperate climates, and ours are traditionally grown climbing along metallic wires. As the vine grows, a second wire structure is built to attach the stems on the wires. This helps ensure that the stems are turning clockwise to follow the sun throughout the day. The flowers are cut from the second year after planting, from the end of August and throughout September. After harvesting, the hops are cut back to spur regrowth. Hops fields are replanted after 25 years, as the yield begins to wane after this point.

“Hops are cultivated following the best agricultural practices and, by sourcing a co product, we’re bringing a great added value to our suppliers.”

Carla Magny,
Global Category Buyer EMEA

Our Commitment

Ensuring quality and traceability

Lifenol™ hops enjoy full traceability and strict quality monitoring from field to final product. We select varieties of female hops with a high content of specific prenylflavonoids, and carefully screen the raw materials to validate the species and identify potential adulterants.

Sustainably sourced

Our hops are sourced exclusively from Hallertau – the world hops capital – in Germany, from suppliers who are genuine partners. Their expertise and care for the unique environment in which they operate ensures that the high quality raw material that powers Lifenol™ is delivered in a sustainable manner with full traceability from field to final product.

By working together, we ensure all our suppliers share our commitment to responsible sourcing.

Why Givaudan?
Botanical expertise
Explore our trusted, natural ingredients–sustainably sourced with rigorous quality control.
Science & technology
Innovate with our science-backed ingredients with proven health, wellbeing and nutritional benefits.
Enjoyable food experiences
Create unique products with the right taste, colour, texture and functional ingredients.
The latest consumer insights
Transform consumer needs into outstanding products.
Discover more
References

Enhanced nutrition in any application

OatWell™ offers multiple functional benefits for food formulations, making it a versatile ingredient and allowing for fibre fortification in many applications, including bread, crackers, pastas, sweet baked goods and extruded snacks.

OatWell™ behaves as a natural stabiliser/emulsifier, making it an ideal ingredient for clean label strategies, while its high viscosity can deliver thickening properties. In applications such as bakery or processed meats, it exhibits water binding capacities, which hold potential for fat reduction. For classic applications, such as crackers and cereals, it can add a satisfying crisp.
11.4g
of OatWell™ BG28 delivers: 3g of oat beta glucan, 5.6g of dietary fibre and only 32Kcal

Designed for your formulation needs

The Oatwell™ range offers varying levels of total dietary fibre, oat beta-glucan and protein content, as well as different particle sizes. Its unique characteristics make it easy to incorporate in application while meeting taste and nutritional targets for a truly enjoyable consumer experience.

Baked goods

  • Easy to incorporate
  • Water binding capacity and moisture retention help extend shelf life
  • Can be mixed in binder syrup to provide thickness
  • High viscosity delivers thickening properties and texture
  • Enables some fat reduction in cakes
  • Improves overall nutritional profile

Extruded cereals / Snacks

  • Easy to incorporate
  • Excellent format to deliver high content of oat beta-glucan and fibre
  • Good expansion properties
  • Lighter, aerated and crispy texture
  • No colour impact
  • Improves overall nutritional profile

Pasta

  • Easy to incorporate
  • Water binding
  • Comparable texture to regular pasta
  • Improves overall nutritional profile

RTM Powders

  • Free flowing and easy to blend
  • Good dispersion
  • Can deliver added mouthfeel
  • Texture may add to perception of satiety
  • Improves overall nutritional profile

A little product for a lot of nutrition

Our OatWell™ Bran BG28 has over 50% total fibre and 28% beta-glucan. This beta-glucan is a powerful fibre and can help achieve different health claims around the globe. For example in the US, using the heart health claim requires delivering 3g of beta-glucan/day. 

Unique properties to deliver unmatched benefits from oats

For over 30 years, OatWell™ has been researched to develop innovative oat products. Much of our work has focused on proving the health benefits of oat beta-glucans in order to deliver premium value to our customers.

A unique nutritional profile

Generally considered healthier and more nutritious than the other main cereals, oats offer a full range of benefits in a single ingredient. OatWell™ can be provided in three different concentrations of beta-glucans, all delivering both soluble and insoluble fibres, along with an average of 21% - 23% protein.

A proprietary production process

OatWell™ uses a unique production process to fractionate the oat kernel into three product lines: beta-glucan products, oat flours, and oat oils. Our production process preserves the native structure of oat beta-glucans, retaining their high molecular weight during fractionation into oat brans with a high amount of beta-glucans.

The importance of high molecular weight

The molecular weight of oat beta-glucan is essential to delivering health benefits. OatWell™'s beta-glucan has a very high molecular weight (2000-2500 kDa as naturally found in oats), which contributes to its unique viscosity and thickening properties. This viscosity has an important impact on physiological functions, such as reducing blood cholesterol levels, moderating blood glucose and insulin levels, and potentially benefiting satiety.

Benefits of OatWell’s high molecular weight:

  • Ability to effectively reduce cholesterol and maintain healthy blood sugar levels compared to low molecular weight alternatives
  • High viscosity – thickening properties
  • Excellent water-binding properties
  • Potential to replace fat in product formulations

Unlocking the potential of dietary fibres and oat beta-glucan

Dietary fibre is an essential part of a healthy diet, promoting digestive health and providing a range of benefits that can help maintain overall wellbeing. Found in fruits, vegetables, grains, and legumes, dietary fibres are carbohydrates that cannot be digested by the body.

Nutrition Facts Label: FDA definition of “dietary fibre”

"non-digestible soluble and insoluble carbohydrates (with 3 or more monomeric units), and lignin that are intrinsic and intact in plants; isolated or synthetic non-digestible carbohydrates (with 3 or more monomeric units) determined by FDA to have physiological effects that are beneficial to human health."⁸

Soluble Fibers

Soluble fibres are dispersible in water. Fibres with high molecular weight, such as OatWell™, transform into a gel-like substance as they move through the digestive tract, where they are fermented by beneficial bacteria.⁹ This type of fibre is known to reduce cholesterol levels, particularly LDL (bad cholesterol)¹⁰, and manage blood glucose levels⁷ making it particularly beneficial for those concerned with heart health and healthy blood glucose. When soluble fibre, such as that found in Oatwell™, is digested by beneficial bacteria in the large intestine, it acts as a prebiotic.¹¹ As a result of digestion, short chain fatty acids (SCFAs) are released in the colon and serve as a nutrition source for the colon’s own cells.

Oat beta-glucans

One exceptional soluble fibre is beta-glucan, a natural, indigestible polysaccharide found in oats, barley, yeast, bacteria, algae, and mushrooms. Oats are particularly rich in beta-glucan, with concentrations ranging from 3-5% depending on the variety. Oat bran, produced by removing the starchy content of the grain, contains the highest concentration of beta-glucan, offering numerous health benefits for cardiovascular health⁵ ⁶, glycaemic response⁷ and the gut microbiome.⁴

Insoluble fibres

Insoluble fibres, on the other hand, do not dissolve in water as they pass through the digestive system. They help promote regular bowel movements, helping the stool pass more quickly through the intestines, which studies indicate is associated with a reduced risk of colorectal cancer.¹² By delivering both insoluble and soluble dietary fibres, including beta-glucans,¹³  OatWell™ helps meet consumer expectations for nutritious and delightful food experiences while promoting overall wellbeing. Embrace the power of these natural ingredients to create food experiences that truly resonate with today's health-conscious consumers.

Prebiotic support for the gut microbiome

Oat fibre contributes to improved gut health by increasing faecal bulk, but there’s more to the story. OatWell™ oat bran fibre has prebiotic effects, promoting the growth of beneficial bacteria. These bacteria produce short-chain fatty acids like butyrate and propionate, which have been associated with anti-inflammatory, and cholesterol-lowering properties.²⁰

What is a prebiotic?

Prebiotics are substrates that are selectively utilised by host microorganisms that confer a health benefit. Simply put, they are food for beneficial microbes that live in the human gut. These microbes can produce short chain fatty acids, which are considered beneficial compounds. Most prebiotics are dietary fibres, but not all dietary fibres are prebiotics. Many prebiotic fibres are soluble and some are insoluble.¹¹

The prebiotic effects of oat bran fibre have been validated through years of research. In a review by Malkki and Virtanen, they cite: “in the large bowel, soluble dietary fibre increases the fermentation activity, especially production of butyric acid, enhances growth and colonisation of some probiotic bacterial strains, increases production of microbial mass and thereby aids the removal of nitrogen via faeces. It also increases wet weight of stools, thereby alleviating constipation”.²¹

Research conducted on oat beta-glucan demonstrates that it meets three important criteria, confirming its status as a prebiotic fibre:¹ ²

  • helps produce Short Chain Fatty Acids (SCFAs): acetate, propionate and butyrate³
  • increases lactic acid as well as bifidobacteria and lactobacilli³
  • increases faecal bulk and promotes proper gut function⁴
By nurturing the gut microbiome, OatWell™ is an ideal ally for creating healthy and delightful food experiences that optimize wellbeing from within.
Disclaimer
This web page is intended to provide business-to-business education and information.Its purpose is not intended to communicate to end consumers. Ingredient information is for educational purposes only; specific ingredients are not intended to prevent, treat, mitigate or cure any disease states.
*