Aronox™

Aronox™: natural support for healthy blood flow

Aronia berry extract clinically shown to support heart health

Aronox™ is a proprietary extract of the aronia berry that is clinically shown to support healthy blood flow (endothelial function).¹ Aronox™ offers consumers a natural, effective option to support heart health.
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Benefits

Heart health

Heart health is a global concern

Consumers are increasingly aware of the need to support their heart health. Research shows that 23% of US dietary supplement users are seeking support for heart health, rising to 30% for those aged 55 and older.² Balanced diet and exercise are important elements for heart health. Polyphenols from aronia extracts such as Aronox™ have been shown to support healthy blood flow.³

Clinical evidence

Clinically shown to support blood flow¹

Approved health claims

4 authorised health claims from Health Canada

Natural & sustainable

Aronia sourced sustainably in Poland

Rich in polyphenols

Standardised to 40% polyphenols

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The science behind

Aronox™

Aronox™ – beneficial effects to support healthy blood flow

Aronoxis an aronia berry extract rich in polyphenols and in particular, anthocyanins – bioactive compounds found in fruits and vegetables.¹ Evidence from epidemiological and clinical studies suggests that a high intake of polyphenol-rich foods, including berries, may support heart health.⁴ Randomised controlled trials have also shown significant improvements in blood lipids, blood pressure and endothelial function (blood flow) after the consumption of berries and other foods rich in anthocyanins.¹

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Aronox™

responsible sourcing

Sourcing aronia berries responsibly

The aronia berries we use to create Aronox™ are sustainably cultivated in Poland, following the principles of our Sourcing4Good programme, which promotes responsible practices across our supply chains, while improving both producer livelihoods and the environmental impacts of our products.

Our aronia suppliers are committed to our responsible sourcing practices, and we work closely with them to support you throughout your sustainability journey. Together, we continue to drive tangible actions to protect and promote the environment and the wellbeing of the communities where we source ingredients and operate our facilities.

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Why formulate

with

Aronox™

?

Aronox™ is a 100% water-soluble product, making it ideal for a wide variety of dietary nutraceuticals applications.
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FAQs

1. Why is endothelial function an important marker for health?
2. How fast does Aronox™ work?

We would love to hear from you!

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References

Aronox™

The natural adaptogen backed by science

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The science behind Aronox™

Aronox™ – beneficial effects to support healthy blood flow

Aronox™ is an aronia berry extract rich in polyphenols and in particular, anthocyanins – bioactive compounds found in fruit and vegetables.¹ Evidence from epidemiological and clinical studies suggests that a high intake of polyphenol-rich foods, including berries, may support heart health.⁴ Randomised controlled trials have also shown significant improvements in blood lipids, blood pressure and endothelial function (blood flow) after the consumption of berries and other foods rich in anthocyanins.¹

4
health claims³
1.2%
improvement in endothelial function⁶⁻⁷

Supporting endothelial function to improve blood flow

In a 2019 peer-reviewed publication of a clinical study, 500mg of Aronox™ was shown to have both immediate and long-term effects on the improvement of endothelial function and blood flow (two hours after ingestion and following 90 days of daily consumption).¹ Endothelial cells line the entire circulatory system, from the heart to the smallest capillaries, and control the relaxation (vasodilation) and contraction (vasoconstriction) of blood vessels to manage blood flow⁵. A 1% improvement in endothelial function has been reported to support heart health.⁶ ⁷

Supporting key cardiovascular markers

Other peer-reviewed publications of clinical studies on Aronox™ have demonstrated:

  • 200 mg of aronia polyphenols from Aronox™ has been shown to improve arterial function – measured as augmentation index (AIx) and pulse wave velocity (PWv) and to significantly increase gut microbiome gene richness and the abundance of butyrate-producing species (such as Lawsonibacter asaccharolyticus and Intestinimonas butyriciproducens species) in pre-hypertensive middle-aged individuals.⁸
  • 200 mg of aronia polyphenols from Aronox™ decreases total cholesterol, LDL (“bad”) cholesterol by 11.5 points (p < 0.01) and triglycerides by 27 points (p < 0.05), while maintaining levels of HDL (“good”) cholesterol, in two months in 25 patients with metabolic syndrome.⁹
  • 200 mg of aronia polyphenols from Aronox™ lowers blood pressure, including a decrease in systolic blood pressure (11 mmHg) from high to pre-hypertensive levels (p < 0.000) in just one month in a population of forty-four participants (11 women and 33 men, mean age 66 years) who survived myocardial infarction and have received statin therapy for at least 6 months.¹⁰
  • 200 mg of aronia polyphenols from Aronox™ inhibits the activity of angiotensin converting enzyme (ACE) with a mean decrease of 33.28% (p<0.009) in a population of forty-four participants (11 women and 33 men, mean age 66 years) who survived myocardial infarction and have received statin therapy for at least 6 months. ACE indirectly increases blood pressure by causing blood vessels to constrict, thereby reducing blood flow. ¹⁰ A 2015 in vitro study showed Aronox™ increases levels of nitric oxide. Increased nitric oxide levels have been suggested as a mechanism of action to support vasodilation and blood flow.¹¹
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Multiple approved health claims in Canada³

Aronox™ has been awarded four health claims by Health Canada³:

Helps to support healthy blood flow.

Helps to support healthy endothelial function.

Helps maintain endothelium-dependent vasodilation, which contributes to normal blood flow.

Source of antioxidant(s)/Provides antioxidant(s) that help(s) fight/protect (cell) against/reduce (the oxidative effect of/the oxidative damage caused by/cell damage caused by) free radicals.

References

Aronox™ Responsible Sourcing

Promoting sustainable agricultural practices

As part of our commitment to source all materials and services in a way that protects people and the environment by 2030, we work with our suppliers to ensure trust and compliance across our supply chain.

“We've been working hand in hand with our suppliers for decades to improve quality and implement good agricultural practices in order to walk the talk on our sustainability journey.”

Mateusz Gwizdz,
Global Category Buyer Eastern Europe

Our Commitment

Responsible sourcing

We source our aronia berries from Poland, which is the world’s leading producer. The harvest takes place in late summer and early fall, when the berries are rich in active polyphenols. Our suppliers are aligned with the philosophy of our comprehensive Sourcing4Good programme, which promotes sustainable agricultural practices. These include environmental management principles that avoid any pollution of air, soils and water and, in parallel, conserve biodiversity and nature. 

Why Givaudan?
Botanical expertise
Explore our trusted, natural ingredients–sustainably sourced with rigorous quality control.
Science & technology
Innovate with our science-backed ingredients with proven health, wellbeing and nutritional benefits.
Enjoyable food experiences
Create unique products with the right taste, colour, texture and functional ingredients.
The latest consumer insights
Transform consumer needs into outstanding products.
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References

Enhanced nutrition in any application

OatWell™ offers multiple functional benefits for food formulations, making it a versatile ingredient and allowing for fibre fortification in many applications, including bread, crackers, pastas, sweet baked goods and extruded snacks.

OatWell™ behaves as a natural stabiliser/emulsifier, making it an ideal ingredient for clean label strategies, while its high viscosity can deliver thickening properties. In applications such as bakery or processed meats, it exhibits water binding capacities, which hold potential for fat reduction. For classic applications, such as crackers and cereals, it can add a satisfying crisp.
11.4g
of OatWell™ BG28 delivers: 3g of oat beta glucan, 5.6g of dietary fibre and only 32Kcal

Designed for your formulation needs

The Oatwell™ range offers varying levels of total dietary fibre, oat beta-glucan and protein content, as well as different particle sizes. Its unique characteristics make it easy to incorporate in application while meeting taste and nutritional targets for a truly enjoyable consumer experience.

Baked goods

  • Easy to incorporate
  • Water binding capacity and moisture retention help extend shelf life
  • Can be mixed in binder syrup to provide thickness
  • High viscosity delivers thickening properties and texture
  • Enables some fat reduction in cakes
  • Improves overall nutritional profile

Extruded cereals / Snacks

  • Easy to incorporate
  • Excellent format to deliver high content of oat beta-glucan and fibre
  • Good expansion properties
  • Lighter, aerated and crispy texture
  • No colour impact
  • Improves overall nutritional profile

Pasta

  • Easy to incorporate
  • Water binding
  • Comparable texture to regular pasta
  • Improves overall nutritional profile

RTM Powders

  • Free flowing and easy to blend
  • Good dispersion
  • Can deliver added mouthfeel
  • Texture may add to perception of satiety
  • Improves overall nutritional profile

A little product for a lot of nutrition

Our OatWell™ Bran BG28 has over 50% total fibre and 28% beta-glucan. This beta-glucan is a powerful fibre and can help achieve different health claims around the globe. For example in the US, using the heart health claim requires delivering 3g of beta-glucan/day. 

Unique properties to deliver unmatched benefits from oats

For over 30 years, OatWell™ has been researched to develop innovative oat products. Much of our work has focused on proving the health benefits of oat beta-glucans in order to deliver premium value to our customers.

A unique nutritional profile

Generally considered healthier and more nutritious than the other main cereals, oats offer a full range of benefits in a single ingredient. OatWell™ can be provided in three different concentrations of beta-glucans, all delivering both soluble and insoluble fibres, along with an average of 21% - 23% protein.

A proprietary production process

OatWell™ uses a unique production process to fractionate the oat kernel into three product lines: beta-glucan products, oat flours, and oat oils. Our production process preserves the native structure of oat beta-glucans, retaining their high molecular weight during fractionation into oat brans with a high amount of beta-glucans.

The importance of high molecular weight

The molecular weight of oat beta-glucan is essential to delivering health benefits. OatWell™'s beta-glucan has a very high molecular weight (2000-2500 kDa as naturally found in oats), which contributes to its unique viscosity and thickening properties. This viscosity has an important impact on physiological functions, such as reducing blood cholesterol levels, moderating blood glucose and insulin levels, and potentially benefiting satiety.

Benefits of OatWell’s high molecular weight:

  • Ability to effectively reduce cholesterol and maintain healthy blood sugar levels compared to low molecular weight alternatives
  • High viscosity – thickening properties
  • Excellent water-binding properties
  • Potential to replace fat in product formulations

Unlocking the potential of dietary fibres and oat beta-glucan

Dietary fibre is an essential part of a healthy diet, promoting digestive health and providing a range of benefits that can help maintain overall wellbeing. Found in fruits, vegetables, grains, and legumes, dietary fibres are carbohydrates that cannot be digested by the body.

Nutrition Facts Label: FDA definition of “dietary fibre”

"non-digestible soluble and insoluble carbohydrates (with 3 or more monomeric units), and lignin that are intrinsic and intact in plants; isolated or synthetic non-digestible carbohydrates (with 3 or more monomeric units) determined by FDA to have physiological effects that are beneficial to human health."⁸

Soluble Fibers

Soluble fibres are dispersible in water. Fibres with high molecular weight, such as OatWell™, transform into a gel-like substance as they move through the digestive tract, where they are fermented by beneficial bacteria.⁹ This type of fibre is known to reduce cholesterol levels, particularly LDL (bad cholesterol)¹⁰, and manage blood glucose levels⁷ making it particularly beneficial for those concerned with heart health and healthy blood glucose. When soluble fibre, such as that found in Oatwell™, is digested by beneficial bacteria in the large intestine, it acts as a prebiotic.¹¹ As a result of digestion, short chain fatty acids (SCFAs) are released in the colon and serve as a nutrition source for the colon’s own cells.

Oat beta-glucans

One exceptional soluble fibre is beta-glucan, a natural, indigestible polysaccharide found in oats, barley, yeast, bacteria, algae, and mushrooms. Oats are particularly rich in beta-glucan, with concentrations ranging from 3-5% depending on the variety. Oat bran, produced by removing the starchy content of the grain, contains the highest concentration of beta-glucan, offering numerous health benefits for cardiovascular health⁵ ⁶, glycaemic response⁷ and the gut microbiome.⁴

Insoluble fibres

Insoluble fibres, on the other hand, do not dissolve in water as they pass through the digestive system. They help promote regular bowel movements, helping the stool pass more quickly through the intestines, which studies indicate is associated with a reduced risk of colorectal cancer.¹² By delivering both insoluble and soluble dietary fibres, including beta-glucans,¹³  OatWell™ helps meet consumer expectations for nutritious and delightful food experiences while promoting overall wellbeing. Embrace the power of these natural ingredients to create food experiences that truly resonate with today's health-conscious consumers.

Prebiotic support for the gut microbiome

Oat fibre contributes to improved gut health by increasing faecal bulk, but there’s more to the story. OatWell™ oat bran fibre has prebiotic effects, promoting the growth of beneficial bacteria. These bacteria produce short-chain fatty acids like butyrate and propionate, which have been associated with anti-inflammatory, and cholesterol-lowering properties.²⁰

What is a prebiotic?

Prebiotics are substrates that are selectively utilised by host microorganisms that confer a health benefit. Simply put, they are food for beneficial microbes that live in the human gut. These microbes can produce short chain fatty acids, which are considered beneficial compounds. Most prebiotics are dietary fibres, but not all dietary fibres are prebiotics. Many prebiotic fibres are soluble and some are insoluble.¹¹

The prebiotic effects of oat bran fibre have been validated through years of research. In a review by Malkki and Virtanen, they cite: “in the large bowel, soluble dietary fibre increases the fermentation activity, especially production of butyric acid, enhances growth and colonisation of some probiotic bacterial strains, increases production of microbial mass and thereby aids the removal of nitrogen via faeces. It also increases wet weight of stools, thereby alleviating constipation”.²¹

Research conducted on oat beta-glucan demonstrates that it meets three important criteria, confirming its status as a prebiotic fibre:¹ ²

  • helps produce Short Chain Fatty Acids (SCFAs): acetate, propionate and butyrate³
  • increases lactic acid as well as bifidobacteria and lactobacilli³
  • increases faecal bulk and promotes proper gut function⁴
By nurturing the gut microbiome, OatWell™ is an ideal ally for creating healthy and delightful food experiences that optimize wellbeing from within.
Disclaimer
This web page is intended to provide business-to-business education and information. Its purpose is not intended to communicate to end consumers. Ingredient information is for educational purposes only; specific ingredients are not intended to prevent, treat, mitigate or cure any disease states. This information is not intended to be used in final consumer products and any use or reference of the intellectual property of Givaudan in the final product may only be made with Givaudan’s prior written permission. The information provided may or may not be applicable to, or satisfy, all regulatory requirements for all global regions. Specific regulatory requirements must be evaluated to ensure compliance within the individual countries and regions.

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