Glucevia™

Naturally supporting metabolic health

A fraxinus extract clinically demonstrated to support healthy blood glucose levels

Supported by patents, Glucevia™ is extracted from the seed of the European ash tree (_Fraxinus angustifolia_) that has been shown to support healthy blood glucose levels. Supported by eight peer-reviewed publications of scientific studies¹⁻⁸ including two human clinical trials, Glucevia™ is a unique natural solution for consumers who wish to balance blood sugar and support metabolic health.
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Benefits

Blood glucose health

The growing interest in blood glucose support

It’s important to keep your blood sugar levels in your target range as much as possible to help avoid long-term negative health consequences.⁹ As part of a healthy lifestyle, consumers are increasingly interested in support for blood glucose and metabolic health. In the US, 45% of consumers surveyed as part of a global survey, said they were “very or extremely concerned about blood glucose levels,” while 40% said they “have plans to address their blood sugar levels over the next year.” ¹⁰

Clinically shown

to support healthy blood glucose levels² ³

Supported

by product-specific health claim from Health Canada

Active compounds (Nuzhenide and GL3)

supported by patents**

Unique

100% extract of Fraxinus angustifolia

Want to know more about OatWell™'s unique characteristics?

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The science behind

Glucevia™

Clinically shown to support healthy blood glucose levels

Supported by patents, Glucevia™ is derived exclusively from the samara of Fraxinus angustifolia. Using a traditional extraction process, we were the first to develop a unique extract standardised to 10% total nuzhenide and GL3¹¹. Nuzehnide and GL3 are naturally occurring Fraxinus compounds associated with healthy blood glucose management.²

Two double-blind, placebo-controlled clinical trials have demonstrated its ability to support healthy blood glucose levels.² ³

See science

Glucevia™

responsible sourcing

Responsibly sourced in the Mediterranean

The ash seeds we use to create Glucevia™ are sustainably sourced from the Mediterranean basin, following the principles of our Sourcing4Good programme, which promotes responsible practices across our supply chains, while improving both producer livelihoods and the environmental impacts of our products.

Explore Our Impact

Fraxinus: From tradition to science

Fraxinus, more usually known as the ash tree, grows throughout Europe, North America and Asia. Its distinctive winged “helicopter” seed is technically called a samara. Ash seeds have historically been used in food – notably in the Moroccan condiment ras el hanout – and traditional medicine.³ Fraxinus seeds were traditionally used in the Mediterranean region for balancing blood sugar.⁵ Ash has a well-established traditional use in teas and infusions throughout the Mediterranean basin.

Why formulate

with

Glucevia™

?

Glucevia™ is ideal for a range of nutraceutical applications, including tablets, capsules, sachets, shots and bars.
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FAQs

1. How quickly does Glucevia™ work?

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If you have a specific product in mind or are curious about how we can assist in your innovation journey, please don't hesitate to get in touch
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References

Glucevia™

The natural adaptogen backed by science

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The science behind Glucevia™

Glucevia™ – clinically shown to support healthy blood glucose

Supported by patents, Glucevia™ is derived exclusively from the samara of _Fraxinus angustifolia_ . Using a traditional extraction process, we were the first to develop a unique extract standardised to 10% total nuzhenide and GL3.(11) Nuzehnide and GL3 are naturally occurring Fraxinus compounds associated with healthy blood glucose management.² Two double-blind, placebo-controlled clinical trials have demonstrated its ability to support healthy blood glucose levels.² ³

28%
decrease in blood glucose after 3 weeks²
9%
decrease in post prandial blood glucose³

Significant reductions in blood glucose, after a meal

In the first clinical study with 16 healthy people, there was a significant 9% decrease in glycaemic area under the blood glucose curve (AUC) after consumption of Glucevia™ compared to placebo³. These findings suggest that Glucevia™ supports the uptake of glucose from the blood into the liver and muscle cells.³

Long-term glycaemic control

The significant benefits of longer-term use of Glucevia™ were demonstrated in a 2014 study in elderly, non-diabetic, overweight/obese people.² Three weeks of taking Glucevia™ resulted in a significant 28% reduction in blood glucose, compared to a non-significant reduction of 8% with a placebo. The researchers also found:

  • A significant reduction in blood levels of fructosamine in the Glucevia™ group. Fructosamine is regarded by the European Food Safety Authority (EFSA) as a relevant indicator of long-term glucose control¹², and it’s the most widely used alternative to HbA1c
  • A significant fall in blood glucose two hours after taking Glucevia™ compared to placebo. The World Health Organization cites the two-hour blood glucose value as one of the key indicators of impaired glucose tolerance and diabetes¹³
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Awarded a product-specific health claim

Glucevia™ has been awarded a proprietary, product-specific health claim from Health Canada: “May support healthy glucose metabolism in combination with a healthy diet."¹⁴

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Awarded a product-specific health claim

Glucevia™ has been awarded a proprietary, product-specific health claim from Health Canada: “May support healthy glucose metabolism in combination with a healthy diet."¹⁴

References

Glucevia™ Responsible Sourcing

Traceability from field to end product

As part of our commitment to source all materials and services in a way that protects people and the environment by 2030, we work with our suppliers to ensure trust and compliance across our entire supply chain. Together we ensure full traceability from field to product.

“Our local presence in Morocco allows us to source fully traceable and qualitative material with eco friendly harvest practices.”

Ahmed Sghir,
Global Category Buyer Morocco

Our Commitment

Robust environmental-management principles

We use a gentle and traditional extraction process to create Glucevia™, and ensure full traceability from field to product. In addition, our suppliers follow the principles of our Sourcing4Good programme, which promotes sustainable agricultural practices. These include environmental management principles that:

  • Avoid any pollution of soils, air and water, including complying with local wastewater treatment regulations
  • Prevent waste production and apply the 5Rs of waste management – reduce, reuse, repair, recycle, recover and/or dispose of in an environmentally friendly way
  • Conserve biodiversity and nature 
  • Assess potential carbon emissions reduction as part of their climate mitigation measures

Why Givaudan?
Botanical expertise
Explore our trusted, natural ingredients–sustainably sourced with rigorous quality control.
Science & technology
Innovate with our science-backed ingredients with proven health, wellbeing and nutritional benefits.
Enjoyable food experiences
Create unique products with the right taste, colour, texture and functional ingredients.
The latest consumer insights
Transform consumer needs into outstanding products.
Discover more
References

Enhanced nutrition in any application

OatWell™ offers multiple functional benefits for food formulations, making it a versatile ingredient and allowing for fibre fortification in many applications, including bread, crackers, pastas, sweet baked goods and extruded snacks.

OatWell™ behaves as a natural stabiliser/emulsifier, making it an ideal ingredient for clean label strategies, while its high viscosity can deliver thickening properties. In applications such as bakery or processed meats, it exhibits water binding capacities, which hold potential for fat reduction. For classic applications, such as crackers and cereals, it can add a satisfying crisp.
11.4g
of OatWell™ BG28 delivers: 3g of oat beta glucan, 5.6g of dietary fibre and only 32Kcal

Designed for your formulation needs

The Oatwell™ range offers varying levels of total dietary fibre, oat beta-glucan and protein content, as well as different particle sizes. Its unique characteristics make it easy to incorporate in application while meeting taste and nutritional targets for a truly enjoyable consumer experience.

Baked goods

  • Easy to incorporate
  • Water binding capacity and moisture retention help extend shelf life
  • Can be mixed in binder syrup to provide thickness
  • High viscosity delivers thickening properties and texture
  • Enables some fat reduction in cakes
  • Improves overall nutritional profile

Extruded cereals / Snacks

  • Easy to incorporate
  • Excellent format to deliver high content of oat beta-glucan and fibre
  • Good expansion properties
  • Lighter, aerated and crispy texture
  • No colour impact
  • Improves overall nutritional profile

Pasta

  • Easy to incorporate
  • Water binding
  • Comparable texture to regular pasta
  • Improves overall nutritional profile

RTM Powders

  • Free flowing and easy to blend
  • Good dispersion
  • Can deliver added mouthfeel
  • Texture may add to perception of satiety
  • Improves overall nutritional profile

A little product for a lot of nutrition

Our OatWell™ Bran BG28 has over 50% total fibre and 28% beta-glucan. This beta-glucan is a powerful fibre and can help achieve different health claims around the globe. For example in the US, using the heart health claim requires delivering 3g of beta-glucan/day. 

Unique properties to deliver unmatched benefits from oats

For over 30 years, OatWell™ has been researched to develop innovative oat products. Much of our work has focused on proving the health benefits of oat beta-glucans in order to deliver premium value to our customers.

A unique nutritional profile

Generally considered healthier and more nutritious than the other main cereals, oats offer a full range of benefits in a single ingredient. OatWell™ can be provided in three different concentrations of beta-glucans, all delivering both soluble and insoluble fibres, along with an average of 21% - 23% protein.

A proprietary production process

OatWell™ uses a unique production process to fractionate the oat kernel into three product lines: beta-glucan products, oat flours, and oat oils. Our production process preserves the native structure of oat beta-glucans, retaining their high molecular weight during fractionation into oat brans with a high amount of beta-glucans.

The importance of high molecular weight

The molecular weight of oat beta-glucan is essential to delivering health benefits. OatWell™'s beta-glucan has a very high molecular weight (2000-2500 kDa as naturally found in oats), which contributes to its unique viscosity and thickening properties. This viscosity has an important impact on physiological functions, such as reducing blood cholesterol levels, moderating blood glucose and insulin levels, and potentially benefiting satiety.

Benefits of OatWell’s high molecular weight:

  • Ability to effectively reduce cholesterol and maintain healthy blood sugar levels compared to low molecular weight alternatives
  • High viscosity – thickening properties
  • Excellent water-binding properties
  • Potential to replace fat in product formulations

Unlocking the potential of dietary fibres and oat beta-glucan

Dietary fibre is an essential part of a healthy diet, promoting digestive health and providing a range of benefits that can help maintain overall wellbeing. Found in fruits, vegetables, grains, and legumes, dietary fibres are carbohydrates that cannot be digested by the body.

Nutrition Facts Label: FDA definition of “dietary fibre”

"non-digestible soluble and insoluble carbohydrates (with 3 or more monomeric units), and lignin that are intrinsic and intact in plants; isolated or synthetic non-digestible carbohydrates (with 3 or more monomeric units) determined by FDA to have physiological effects that are beneficial to human health."⁸

Soluble Fibers

Soluble fibres are dispersible in water. Fibres with high molecular weight, such as OatWell™, transform into a gel-like substance as they move through the digestive tract, where they are fermented by beneficial bacteria.⁹ This type of fibre is known to reduce cholesterol levels, particularly LDL (bad cholesterol)¹⁰, and manage blood glucose levels⁷ making it particularly beneficial for those concerned with heart health and healthy blood glucose. When soluble fibre, such as that found in Oatwell™, is digested by beneficial bacteria in the large intestine, it acts as a prebiotic.¹¹ As a result of digestion, short chain fatty acids (SCFAs) are released in the colon and serve as a nutrition source for the colon’s own cells.

Oat beta-glucans

One exceptional soluble fibre is beta-glucan, a natural, indigestible polysaccharide found in oats, barley, yeast, bacteria, algae, and mushrooms. Oats are particularly rich in beta-glucan, with concentrations ranging from 3-5% depending on the variety. Oat bran, produced by removing the starchy content of the grain, contains the highest concentration of beta-glucan, offering numerous health benefits for cardiovascular health⁵ ⁶, glycaemic response⁷ and the gut microbiome.⁴

Insoluble fibres

Insoluble fibres, on the other hand, do not dissolve in water as they pass through the digestive system. They help promote regular bowel movements, helping the stool pass more quickly through the intestines, which studies indicate is associated with a reduced risk of colorectal cancer.¹² By delivering both insoluble and soluble dietary fibres, including beta-glucans,¹³  OatWell™ helps meet consumer expectations for nutritious and delightful food experiences while promoting overall wellbeing. Embrace the power of these natural ingredients to create food experiences that truly resonate with today's health-conscious consumers.

Prebiotic support for the gut microbiome

Oat fibre contributes to improved gut health by increasing faecal bulk, but there’s more to the story. OatWell™ oat bran fibre has prebiotic effects, promoting the growth of beneficial bacteria. These bacteria produce short-chain fatty acids like butyrate and propionate, which have been associated with anti-inflammatory, and cholesterol-lowering properties.²⁰

What is a prebiotic?

Prebiotics are substrates that are selectively utilised by host microorganisms that confer a health benefit. Simply put, they are food for beneficial microbes that live in the human gut. These microbes can produce short chain fatty acids, which are considered beneficial compounds. Most prebiotics are dietary fibres, but not all dietary fibres are prebiotics. Many prebiotic fibres are soluble and some are insoluble.¹¹

The prebiotic effects of oat bran fibre have been validated through years of research. In a review by Malkki and Virtanen, they cite: “in the large bowel, soluble dietary fibre increases the fermentation activity, especially production of butyric acid, enhances growth and colonisation of some probiotic bacterial strains, increases production of microbial mass and thereby aids the removal of nitrogen via faeces. It also increases wet weight of stools, thereby alleviating constipation”.²¹

Research conducted on oat beta-glucan demonstrates that it meets three important criteria, confirming its status as a prebiotic fibre:¹ ²

  • helps produce Short Chain Fatty Acids (SCFAs): acetate, propionate and butyrate³
  • increases lactic acid as well as bifidobacteria and lactobacilli³
  • increases faecal bulk and promotes proper gut function⁴
By nurturing the gut microbiome, OatWell™ is an ideal ally for creating healthy and delightful food experiences that optimize wellbeing from within.
Disclaimer
This web page is intended to provide business-to-business education and information. Its purpose is not intended to communicate to end consumers. Ingredient information is for educational purposes only; specific ingredients are not intended to prevent, treat, mitigate or cure any disease states. This information is not intended to be used in final consumer products and any use or reference of the intellectual property of Givaudan in the final product may only be made with Givaudan’s prior written permission. The information provided may or may not be applicable to, or satisfy, all regulatory requirements for all global regions. Specific regulatory requirements must be evaluated to ensure compliance within the individual countries and regions.

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Health solutions for breakfast, Friday evening snacking, and snacking on the go!

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