There is a growing body of research explaining Svetol’s™ mechanisms of action. While the research was done ex vivo, it suggests the following mechanisms of action:

• Inhibition of the glucose-6-phosphatase activity, an hepatic enzyme involved in the glucose release from glycogen storage in the liver into blood circulation; this forces lipids to be used as energy to compensate for the decrease in glucose release from glycogenolysis.⁸
• Stimulation of  the release of free fatty acids from human adipocytes (fat cells); thus reducing the adipocyte cell volume, which is defined as a "fat burning" action..⁹

Svetol™’s extensive published research includes:

• 3 clinical studies for weight management¹ ⁴ ⁵
• 3 bioavailability studies showing that the active compounds - chlorogenic acids - are well absorbed by the body⁶
• 2 studies⁸ describing the mechanisms of action: 
  • Indirect stimulation of fat use as an energy source: Inhibits the liver enzyme involved in the release of glucose from glycogen stores. This will stimulate the use of lipids to be used as energy.⁸
  • Direct stimulation of fatty acids release from fat stores, which is defined as having a ‘fat burning’ action.⁹

In a gold-standard randomised, double-blind controlled trial of 50 overweight participants¹, supplementing with 400 mg per day of Svetol™ for 60 days before meals and a low caloric diet resulted in a significant: 

• Decrease in body weight vs. placebo (4.97 kg (5.7%) versus 2.45 kg (2.9%) ; P<0.001)
• Decrease in BMI vs. placebo (1.9 versus 0.9 kg/m²; P<0.001)
• Increase in the ratio of lean mass to fat mass vs. placebo (4.1 versus 1.6%; P<0.01)