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The science behind Lifenol™

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Lifenol™

Clinically proven benefits for menopausal symptoms

Lifenol™ is a natural, low-dose solution delivering effective phytoestrogen, prenylnaringenin (8-PN). A single 85 mg dose has been clinically shown to alleviate distressing menopausal symptoms such as hot flashes and sleep problems in two separate studies.² ³ It is also clinically demonstrated to support bone health.³

1%
increase in bone mineral density³
Improves menopausal symptoms in as little as 6 weeks²

Effectively managing menopausal symptoms

Two independent, randomised, double-blind, placebo-controlled trials have demonstrated that Lifenol™ effectively manages menopausal symptoms, including hot flashes and sleep disturbances. 

  • In the first study, after six weeks of taking 85 mg of Lifenol™ daily, postmenopausal women saw their hot flashes reduced from between two and five per day to less than two per day. They also reported a significant reduction in other symptoms, including night sweats and sleep disturbances, compared to placebo.²
  • The second study found that postmenopausal women switching from eight weeks on placebo to eight weeks on 85 mg of Lifenol™ daily experienced a reduction in menopausal discomfort.² On the other hand, those moving from Lifenol™ to placebo reported a slight increase in symptoms.²

Supporting healthy bone density

A 2023 clinical study – another gold-standard, randomised, double-blind, placebo-controlled trial – has shown that Lifenol™ supports bone health in postmenopausal women with osteopenia.³ Supplementation with 85 mg per day for 48 weeks, along with standard-of-care vitamin D3 and calcium daily supplementation, significantly improved total bone mineral density by 1.8% compared to baseline.³

What’s really interesting is that it increased by 1% compared to supplementation with vitamin D3 and calcium alone. The participants taking Lifenol™ also reported a significant improvement in their physical quality of life and functional health (like participating in vigorous physical activity) compared to placebo.

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Approved health claims

Based on the strong scientific evidence, Lifenol™ has been awarded health claims in two countries.  - The South Korean Ministry of Food and Drug Safety has authorised the health claim on Lifenol™ + Soy extract blend: “May help to maintain female health in menopause.” ⁵ - Health Canada has granted LifenolTM a Natural Product Number and the health claim: “May help relieve menopausal discomforts/complaints.” ⁶

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Approved health claims

Based on the strong scientific evidence, Lifenol™ has been awarded health claims in two countries.

The South Korean Ministry of Food and Drug Safety has authorised the health claim on Lifenol™ + Soy extract blend: “May help to maintain female health in menopause.” ⁵

Health Canada has granted Lifenol™ a Natural Product Number and the health claim: “May help relieve menopausal discomforts/complaints.” ⁶

References
Disclaimer
This web page is intended to provide business-to-business education and information. Its purpose is not intended to communicate to end consumers. Ingredient information is for educational purposes only; specific ingredients are not intended to prevent, treat, mitigate or cure any disease states. This information is not intended to be used in final consumer products and any use or reference of the intellectual property of Givaudan in the final product may only be made with Givaudan’s prior written permission. The information provided may or may not be applicable to, or satisfy, all regulatory requirements for all global regions. Specific regulatory requirements must be evaluated to ensure compliance within the individual countries and regions.
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