The science behind Glucevia™

Glucevia™ – clinically shown to support healthy blood glucose

Supported by patents, Glucevia™ is derived exclusively from the samara of _Fraxinus angustifolia_ . Using a traditional extraction process, we were the first to develop a unique extract standardised to 10% total nuzhenide and GL3.(11) Nuzehnide and GL3 are naturally occurring Fraxinus compounds associated with healthy blood glucose management.² Two double-blind, placebo-controlled clinical trials have demonstrated its ability to support healthy blood glucose levels.² ³

28%

decrease in blood glucose after 3 weeks²

decrease in post prandial blood glucose³

Significant reductions in blood glucose, after a meal

In the first clinical study with 16 healthy people, there was a significant 9% decrease in glycaemic area under the blood glucose curve (AUC) after consumption of Glucevia™ compared to placebo³. These findings suggest that Glucevia™ supports the uptake of glucose from the blood into the liver and muscle cells.³

Long-term glycaemic control

The significant benefits of longer-term use of Glucevia™ were demonstrated in a 2014 study in elderly, non-diabetic, overweight/obese people.² Three weeks of taking Glucevia™ resulted in a significant 28% reduction in blood glucose, compared to a non-significant reduction of 8% with a placebo. The researchers also found:

A significant reduction in blood levels of fructosamine in the Glucevia™ group. Fructosamine is regarded by the European Food Safety Authority (EFSA) as a relevant indicator of long-term glucose control¹², and it’s the most widely used alternative to HbA1c
A significant fall in blood glucose two hours after taking Glucevia™ compared to placebo. The World Health Organization cites the two-hour blood glucose value as one of the key indicators of impaired glucose tolerance and diabetes¹³

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Awarded a product-specific health claim

Glucevia™ has been awarded a proprietary, product-specific health claim from Health Canada: “May support healthy glucose metabolism in combination with a healthy diet."¹⁴

Learn More

Awarded a product-specific health claim

Glucevia™ has been awarded a proprietary, product-specific health claim from Health Canada: “May support healthy glucose metabolism in combination with a healthy diet."¹⁴

Ibarra, A. (2011), ‘Fraxinus excelsior seed extract FraxiPure™ limits weight gains and hyperglycemia in high-fat diet-induced obese mice’, Phytomedicine, 18(6):479-485.
Zulet, M.A. et al. (2014) ‘A Fraxinus excelsior L. seeds/fruit extract benefits glucose homeostasis and adiposity related markers in elderly overweight/obese subjects: a longitudinal, randomized, crossover, double-blind, placebo-controlled nutritional intervention study’, Phytomedicine, 21(10):1162-1169.
Visen, P. (2009) ‘Acute effects of Fraxinus excelsior L. seed extract on postprandial glycemia and insulin secretion on healthy volunteers’, Journal of Ethnopharmacology, 126(2):226-232.
Montó, F. et al. (2014), ‘Action of an extract from the seeds of Fraxinus excelsior L. on metabolic disorders in hypertensive and obese animal models’, Food & function, 5(4):786-796.
García-Villalba, R. et al. (2015) ‘Targeted and untargeted metabolomics to explore the bioavailability of the secoiridoids from a seed/fruit extract (Fraxinus angustifolia Vahl)' in Human Healthy Volunteers: A Preliminary Study’, Molecules, 20(12):22202-22219.
Flanagan J. et al. (2013) ‘Safety evaluation and nutritional composition of a Fraxinus excelsior seed extract, FraxiPure™’, Food and Chemical Toxicology, 53:10-7.
Bai, N. et al. (2010), ‘Iridoids from Fraxinus excelsior with adipocyte differentiation-inhibitory and PPARalpha activation activity’, Journal of Natural Products, 73(1):2-6.
Gómez-García, F.J. (2015) 'Preventive Effect of a Fraxinus Excelsior L Seeds/Fruits Extract on Hepatic Steatosis in Obese Type 2 Diabetic Mice', Journal of Diabetes & Metabolism, 6:1-5.
Centers for Disease Control and Prevention (2022) Manage Blood Sugar. Available at: https://www.cdc.gov/diabetes/managing/manage-blood- sugar.html (accessed 30 September 2022).
Kvidahl Reilly, M. (2023) Blood sugar management gets a holistic makeover. Available at: https://www.nutritionaloutlook.com/view/blood-sugar-management-gets-a-holistic-makeover (accessed 8 February 2023).
US 8,293,292 B2. Granted October 2012.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2012) ‘Guidance on the scientific requirements for health claims related to appetite ratings, weight management, and blood glucose concentrations’, EFSA Journal 2012, 10(3):2604-2615.
World Health Organisation (2016) Global Report on Diabetes. Available at: https://iris.who.int/bitstream/handle/10665/204871/9789241565257_eng.pdf;jsessionid=1DD02DD83615D81699A4F7D3946BC7DD?sequence=1 (accessed January 16 2024).
Health Canada Natural Product Number 80062613. Claim wording: “May support healthy glucose metabolism in combination with a healthy diet”. 10 July 2010. **GluceviaTM technology is described in several Givaudan patent rights.

The science behind Glucevia™

Glucevia™ – clinically shown to support healthy blood glucose

Significant reductions in blood glucose, after a meal

Long-term glycaemic control

Awarded a product-specific health claim

Awarded a product-specific health claim

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